Role of molecular imaging in mouse models of cardiac diseases -small animal-PET to elucidate the pathophysiology in survivin'7'

摘要

This study aims to elucidate the pathophysiological background of the developing heart failure in mice with cardiomyocyte-restricted knockout of survivin (survivin). Molecular and functional imaging methods as positron emission tomography (PET) and magnetic resonance imaging (MRI) were used for non-invasive phenotyping. Serial measurements in surviving and their littermate controls were performed and combined with histological findings, assessing not only the macroscopic enlargement of heart chambers over time in vivo but also compensatory mechanisms on cellular levels such as hypertrophy and enhancement of glucose metabolism.