Study on Poly(β-hydroxybutyrate-co-β-hydroxyvalerate)/Bioglass Composites as Scaffold for Tissue Engineering

摘要

The porous poly(β-hydroxybutyrate-co-β-hydroxyvalerate) (PHBV)/bioactive glasses (BG) tissue engineering scaffold was prepared in this article. The mineralization behavior of the porous PHBV/BG scaffold was observed in simulated body fluid (SBF). The ion concentration of calcium, silicon and phosphorus in different mineralization periods were tested by inductively coupled plasma (ICP). The formation of the hydroxyl carbonate apatite (HCA) layer on the scaffold surface was confirmed by the Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD) apparatus. The micro morphology and porosity of the scaffold before and after mineralization were observed by scanning electron microscopy (SEM). The in vivo biological evaluation of the porous PHBV/BG scaffolds was carried out by implanting the scaffold into the rat muscle to test the biocompatibility. The in vivo result shows that the composite exhibit good biocompatibility. The porous PHBV/BG scaffold is suitable for tissue engineering.