Interstitial single fiber multi-decay-probe for light dosimetry in photodynamic therapy: modelling

摘要

Theoretical considerations concerning new method for interstitial photodynamic therapy light dosimetry and distribution at different depths, by means of single-fiber multi-decay-probes is presented, basing on decomposition of multi-exponential decay. Successful decomposition of up to 25 and up to 7 components of the modelled fiber probe was achieved with noiseless and noise containing decay curves respectively. The impact of noise and distribution of excitation intensity were examined and optimisation algorithm was briefly described.