Adsorption and desorption of interferon onto colloidal hydrophobic surfaces

摘要

Medusa technology for protein delivery is based on the self assembly of amphiphilic polyaminoacids and proteins. The well controlled synthesis of random poly(1-leucin-b-1-glutamate) leads to nanoparticles which adsorb interferon alpha 2b in water. Preclinical results in dogs demonstrate a sustained release of the non denaturated protein over more than 5 days.