ENZYMATIC SYNTHESES OF AROMATIC AMINO ACIDS LABELED WITH CARBON AND HYDROGEN ISOTOPES

摘要

The isotopomers of L-phenylalanine, L-tyrosine, L-tryptophan, and its derivative 5'-hydroxy-L-tryptophan labeled with isotopes of carbon and hydrogen have been obtained using combined chemical and enzymatic routes. The Ba14CO3, l4C-malonic acid, KI4CN, heavy and tritiated water have been used as a sources of stable and radioactive label.