Functionalized Plasmonic Nanostructure Arrays for Direct and Accurate Mapping Extracellular pH of Living Cells Using SERS(PPT)

摘要

1. Q3D-PNAs SERS substrate demonstrated excellent reproducibility. 2. 4-MBAmodifiedQ3D-PNAs SERS substrate can detect the pH variation. Resolution: 0.1 pH unit. 3. Divalent cations influenced the pH detection by 4-MBA. 4. pH_e distributions of normal and tumor cells were mapped and imaged. 5. Tumor cells demonstrated more acid averaged pH_e.