Amorphous solid dispersions (ASDs) of poorly water soluble active pharmaceutical ingredients (APIs) in hydrophilic polymeric matrices are a commonly used strategy to increase the solubility and dissolution rate of oral-dosage forms [1]. However, since the polymer is hydrophilic and the API is poorly water soluble, it is often difficult to find a common solvent for both and a mixture of co-solvents is used instead. Solvent mixtures also offer the possibility of influencing particle morphology and drying rate [2] and have been reported to offer advantages in the solid state drugpolymer miscibility and on the stability of the ASDs [3,4].
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