Powder Characterization and Trouble-Shooting Methods for Successful Process-Scale up(PPT)

摘要

1. Assess the key powder handling concerns prior to scale-up 1.1 Design equipment (bins, hoppers and chutes) for reliable flow at target production rates and reduce risks of segregation and CU variation 1.2 Key batch vs. continuous process concerns may be different 3. Conduct powder characterization tests to assess risk 4. Use powder test outputs as inputs to process & equipment design 5. Utilize trouble-shooting methods during scale-up to address 5.1 Powder flow problems 5.2 Feed rate concerns 5.3 Segregation risks and CU concerns