Infrared-spectroscopy is a powerful method for the study of various biomedical samples concerning an in-vitro analysis in the laboratory and non-invasive diagnostics. Diabetic patients have considerable expectations with respect to a non-invasive blood glucose assay. Non-invasive skin tissue pathology is another area. The analysis of biofluids such as whole blood, plasma, serum and urine can be carried out simultaneously and rapidly without the need for reagents for a multitude of analytes. Dry film measurements by near and mid-infrared spectroscopy will be involved in future analytical tools for the clinical chemistry laboratory. Recent developments in infrared silver halide fibers allow the fabrication of flexible fibre-optic probes for the measurement of biosamples of sub-microliter volumes. Based on human micro-dialysates, the development of a quantitative glucose assay is most interesting for diabetes diagnostics and therapy. Other applications include the measurement of skin within dermatology studies with the aim of a pathological assessment of abnormal skin or the pharmacokinetics of the penetration of active ingredients such as vitamins and constituents of cosmetic cream formulations into human skin.
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