Diffusion and electrophoresis in gels: going beyond standard Ogston and free volume models

摘要

This presentation will start with an overview of the recent progress made in the development and application of our lattice model of low-field gel electrophoresis (the so-called "Ogston regime"). This model, which allows numerically exact results tobe obtained, can also be used to study a wide range of diffusion problems in a variety of disciplines. In particular, we will look at the dynamics of oligomers and spherical analytes in ordered and disordered gels, including the case of a thermodynamic ratchet system. We will then discuss how the model can be extended to treat the following situations: electric field lines going around non-conducting obstacles; inhomogeneous systems; high electric field intensities; and the limit to the continuum.