Pre- and post-natal inflammatory events in chronic lung disease of preterm infants

摘要

These data indicate that a complex cytokine-induced lung injury responsible for CLD may begin prior to birth in a subset of preterm infants exposed to chroioamnionitis. The antenatal events may prime pulmonary tissue such that minimally injurious events in the postnatal period provoke an excessive locally inflammatory response in infants with RDS and CLD which could affect normal alveolarization and pulmonary vascular development and promote growth arrest of the immature lung.