Thermal Field-Flow Fractionation as a Polymer Separation Technique for MALDITOF MS.

摘要

Thermal field-flow fractionation (ThFFF) is coupled with MALDITOF MS to analyze high polydispersity polymers and polymer mixtures.1 Problems associated with MALDI MS include mass discrimination of higher molecular weight (MW) components and selective signal loss of one polymer component.2-5 Generally, MALDITOF MS analyses of highly polydispersed and chemically heterogeneous polymer samples require preliminary fractionation of the sample according to MW or/and chemical composition.