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New Catalysts for the Carbonylation of Phenol: Discovery Using High-Throughput Screening and Leads Scale-Up

机译:苯酚的羰基化的新催化剂:使用高通量筛选和引线进行扩大的发现

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The production of DPC via a one-step process (Figure 1) is highly desired by industry. The key to the economic viable of this route is in the optimization of the catalysis system. Current catalysts are multi-component mixtures of metal salts, a halide sources and co-factors (See Table 1 for an example formulation). In order to discover new catalysts and optimize existing ones a high-throughput screening system was developed to run multiple chemical reactions in parallel on a small scale. High throughput experimentation has been used successfully since the 1970s to spend the development of new materials.
机译:通过一步过程(图1)生产DPC由工业受到高度期望。该路线经济可行的关键是催化系统的优化。目前的催化剂是金属盐,卤化物源和共源的多组分混合物(见例制剂的表1)。为了发现新的催化剂并优化现有的筛选系统,开发出高通量筛选系统以在小规模上并行运行多种化学反应。自20世纪70年代以来成功地使用了高吞吐量实验,以便在开发新材料。

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