Wistar male rats were exposed to toner 6hrs/day, 5days/week for 2 years at 2 exposure concentration level, that is 5 and 15mg/m3. MMAD and GSD of toner particles in the chamber were 4.5μm and 1.3 respectively. Rats were sacrificed at 1 year exposure(each 10 rats) and at 2 years exposure(all remained rats). There is no difference in mortality and body(organ) weights between 2 exposure rats and controls. Lung burden of toner were determined by color imaging method. Pulmonary deposition and clearance of toner particles were mathematically estimated using the biological half time of MMMF in normal clearance condition. The clearance of high-dose exposure group was extremely prolonged at the end of exposure compared with the estimated value. This results shows that the lung burden in high-dose exposure was overloaded and induced the impairment of alveolar macrophage clearance and the excessive quantity in lung.
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机译：Wistar雄性大鼠暴露于调色剂6小时/天，5天/周，2年，2年，2年，即5和15mg / m 3。腔室中的调色剂颗粒的MMAD和GSD分别为4.5μm和1.3。大鼠在1年暴露（每10只大鼠）和2年暴露（所有剩余的大鼠）中处死。 2个暴露大鼠和对照之间的死亡率和身体（器官）重量没有差异。通过彩色成像方法测定肺部调色剂的负担。使用正常间隙条件下的MMMF的生物半时间来数学估算调色剂颗粒的肺部沉积和清除。与估计值相比，高剂量暴露组的间隙极其延长。结果表明，高剂量暴露中的肺负担被过载，诱导肺泡巨噬细胞间隙的损害和肺中过量的量。
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