High multi-drug resistance to chemically unrelated oomycete fungicides in Phytophthora infestans and P. nicotianae

摘要

Fungicide research has produced a diverse range of new oomycete fungicides, such as morpholines, amidocarbamates, Qols, Qils and benzamides, which are expected to have a significant impact on the control of downy mildews. Biochemical studies on the mode of action showed that their fungitoxicity is based on different mechanisms of action from those of phenylamides and acetamides, which interfere with nucleic acid (RNA and DNA, respectively) biosynthesis (Ziogas & Davidse, 1987). To our knowledge verylimited information is available concerning the risk for resistance development to the above novel fungicides. The objective of the present study was to explore the genetical potential of Phytophora infestans and P. nicotianae for resistance to new oomycete fungicides and to access the risk related to the build-up of field resistance. The research project was co-funded by the European Social Fund and National Resources - EPEAEKII.