Function of the G-CSF receptor in hematopoietic differentiation

摘要

Granulocyte colony-stimulating factor (G-CSF) is the major hematopoietic growth factor involved in the control of neutrophil development. G-CSF activates a receptor of the hematopoietin receptor superfamily, which subsequently triggers multiple signaling mechanisms, including the activation of JAKs and STATs. Here, we discuss our current understanding of how these mechanisms are thought to contribute to the specific responses of myeloid progenitor cells to G-CSF.