Forkhead Transcription Factors: New Targets Of Protein Kinase B (C-Akt) Signalling

摘要

The proto-oncogene protein kinase B (PKB), also known as c-Akt, is a central player in a signalling pathway of which many components have been linked to tumorgenesis. Roles for PKB in control of metabolism and survival as well as insulin-mediated transcription have been suggested. No transcription factor downstream of insulin-activated PKB, however, has yet been described. Here, we discuss the data that revealed the Forkhead transcription factors AFX, FKHR and FKHRL1 to be direct substrates of PKB and the implications of this finding on our understanding of PKB function.