ELECTRIC FIELD EFFECTS ON THE SELF-ASSEMBLY AND HYBRIDIZATION OF FUNCTIONALIZED OLIGONUCLEOTIDES

摘要

DNA and DNA hybridization is increasingly being employed in the fabrication of 2D and 3D self-assembled films of potential applicability.However,to exploit fully and meaningfully the potential technological innovations these systems offer it is necessary to improve the presently available methods for DNA film preparations and hybridizations.We report here the electric field effect on the self-assembly of functionalized oligonucleotide (single stranded short chain DNA,ssDNA) films and then-hybridized counterparts (double stranded short chain DNA,dsDNA).Two relatively simple complimentary pairs of thiol functionalized oligonucleotides,O12 -