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Small-angle neutron scattering of bilayer vesicles made with synthetic phospholipids

机译:用合成磷脂制成的双层囊泡的小角度散射

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We have used Small-Angle Neutron Scattering to investigate the structure of bilayer lipid membranes in aqueous solution. The lipids consist of equimolar concentrations of two molecules DMPG and DMPC (see text). The structures consist of solvent filled cores surrounded by shells composed of the lipid bilayers. In particular the radii of the core and shell thickness are measured as a function of lipid concentration and temperature. Other features which reveal themselves are vesicle forming ability of the lipids, additional larger structures and inter-vesicle interactions at large vesicle concentrations. The study is motivated by the possible use of these systems as delivery vehicles for various beneficial therapeutic compounds.
机译:我们已经使用了小角度散射来研究水溶液中双层脂膜的结构。脂质由两分子DMPG和DMPC的等摩尔浓度组成(参见文本)。该结构由由由脂质双层组成的壳包围的溶剂填充芯。特别地,测量芯和壳厚度的半径作为脂质浓度和温度的函数。揭示自己的其他特征是脂质的囊泡形成能力,额外的较大结构和大小囊泡浓度的囊泡相互作用。该研究通过这些系统可能使用这些系统作为各种有益治疗化合物的递送载体。

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