De novo design and synthesis of amphiphilic alpha -helical peptides

摘要

Previous studies indicate successful results on the bundles of amphiphilic transmembrane alpha -helices as a structural motif for ion-channel proteins. Thus, the de novo design and synthesis of amphiphilic alpha -helical peptides become practical ways for the artificial modeling of channel proteins [1]. On the basis of secondary structure prediction and molecular modeling, we design, synthesize and characterize three amphiphilic heneicosapeptides, LSSLLGLLSSLLP LLSSLLXX, X=K(I), X=E(II), EALAKLLEALAKLLEALA KLK(III).