3D STRUCTURE OF HiPEPs IN SOLUTION THROUGH NMR AND MOLECULAR DYNAMICS STUDIES

摘要

The detailed structural characterization of a protein is a fundamental step for the understanding of its biological function. Such characterization can be carried out through X-ray studies. However, the latter have to be performed in the solid state and consequently information on the structural and dynamic features of protein in solution is not achieved, Furthermore, in several cases single crystals might not be available due to the difficulties of crystallization or to the instability of the compound, especially when protein-substrate adducts are to be analyzed.