This chapter provides a broad overview of the development of transgenic crops system for plant-resistance to insects. As of 2001, the only transgenic crops that were commercially available on a worldwide scale were those that contain the Cry proteins from the soil bacterium, Bacillus thuringiensis (Bt). The impact of Bt on non-target organisms, including mammals and man, economic benefit for growing transgenics, and resistance management strategies designed to preserve this vital technology, are discussed.
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