NUMERICAL INVESTIGATION OF HEAT TRANSFER IN TISSUES DURING THERAPEUTIC HYPERTHERMIA

摘要

A numerical analysis is conducted to study the thermal behavior of human healthy and cancerous tissues during magnetic nanoparticle hyperthermia treatment. A transient multi-layer two-dimensional model is developed using commercial CFD package, ANSYS-FLUENT 18.1. The impact of therapeutic heat generation rate and various tissue cooling conditions on the thermal response of the tumor and normal tissues are investigated. It was found that the tumor temperature is not affected by different cooling conditions while the temperature of healthy tissues around tumor is significantly impacted. The results also demonstrated that the effective tumor temperature can be achieved in approximately ten minutes by using therapeutic heat generation rate of 150 kW/m~3 in all three cooling conditions.