Relating Atrial Appendage Flow Stasis Risk from Computational Fluid Dynamics to Imaging Based Appearance Paradigms for Cardioembolic Risk

摘要

Emboli originating from the left atrial appendage are a major cause of transient ischemic attack and cardioembolic stroke. Whereas this risk has been shown to be correlated with left atrial appendage morphology (Cactus, Chicken Wing, Windsock, and Cauliflower shapes) determined from 3D imaging, this clinical correlation is found wanting with regard to a biomechanically grounded underlying basis for thrombosis based on intra-atrial hemodynamics. We define a novel probabilistic risk stratification paradigm for intra-atrial flow stasis based on personalized computational fluid dynamics.