Simulation of circadian temporal organization of the lymph node system using the automated expert program SMLN

摘要

The combination of somatic and visceral lymph nodes plays a leading role in the formation of the daily internal temporal order of the lymphoid system. Using the apparatus of mathematical modeling of the lymphocytes movement provides an integrative picture of the temporal organization of cellular and tissue kinetics of lymph nodes of different locations. Regional differences in the formation of daily biorhythms of cellular composition, activity of drainage systems, lymphoid structures and microenvironment of lymph nodes in connection with the rhythms of nutrition, motor activity, sleep-wakefulness are characterized. The influence of the genetic factor on the spatial-temporal organization of dynamic processes in the lymph nodes of different localization was revealed. The power and directivity of the fluxes of cellular movements, as well as the fluid balance cause different strength of the immune response of different phases of the daily cycle.