Effect of GHR variation on mandibular height

摘要

Growth hormone (GH) is a hormone produced by the acidophil of the anterior pituitary gland that affects the growth and development of craniofacial structures. GH must bind to the growth hormone receptor (GHR) to stimulate the target site. As GH is the primary regulator of bone growth, the GHR plays an important role in determining morphological traits. The GHR is also found in the condyle region. Few studies have examined the correlation between variation in the GHR and mandibular height in Korean, Japanese, and Han Chinese populations. These studies showed that amino acid substitutions at P561T, C422F, and 1526L were correlated with mandibular height. Various environmental factors contribute to mandibular morphogenesis, but we know that genetic factors also play a considerable role. Previous studies revealed correlations between genetic variants of GHR and mandibular morphogenesis. Knowledge of the genetic markers involved in craniofacial morphogenesis will allow clinicians to more easily predict orthopedic reactions in advance of treatment.