Brushite Bone Cement Prepared from Granular Hydroxyapatite and β-Tricalcium Phosphate

摘要

The properties of brushite cement were manipulated by partially replacing β-tricalcium phosphate with dense granular hydroxyapatite (HA). The introduction of HA granules resulted in prolonged setting time as well as reduction of temperature rise during setting. The changes produced by addition of HA granule were useful for drug loading. HA granules, prepared by spray drying, could preserve a meaningful 4.5 wt% of gentamicin sulfate solution. However, HA granules with excessive setting agent resulted in formation of dicalcium phosphate instead of brushite.