Population Pharmacokinetics of Levetiracetam and Zonisamide in the African Grey Parrot (Psittacus erithacus)

摘要

Population pharmacokinetics of either levetiracetam (n = 8) and zonisamide ( = 7) were determined from therapeutic drug monitoring data in epileptic African grey parrots. Mean "trough" concentrations were 5.0 ± 3.6 ug/ml at 11.3 ± 1.49 mg/kg for levetiracetam (11 ± 1.5 hours) and 10.4 ±4.0 ug/ml at 10.9 ± 1.4 mg/kg for zonisamide (11 ± 1.3 hours). Based on rate constants, disappearance half-life (hours) was 2.3 ± 0.029 for levetiracetam and 10.9 ± 18 hours for zonisamide. No animal was controlled. Individual variability necessitates monitoring.