The First Total Synthesis of Ganglioside HPG-7

摘要

A new ganglioside species, HPG-7 was isolated from the sea cucumber, Holothuria pervicax [1]. The HPG-7 showed neuritogenic activity toward the rat pheochromocytoma cell line (PC-12), and has an extremely rare molecular structure, which are an inner trisialic acid residue with different glycosyl linkages, fucosyl-a(1->4)sialoside, and a phytoceramide with branched alkyl chain. Herein, we report the first total synthesis of the HPG-7 as a part of our synthetic study on complex echinodermatous gangliosides.