C- AND 5-GLYCOSYLATIONS OF N-ACETYLNEURAMINIC ACID DERIVATIVES

摘要

Sialic acids, found in bioconjugates, are a family of nonulosonic acids; their biological functions derive both from their size and their natural position as the terminal residue on cell surface glycoconjugates. They are directly involved in cell-to-cell, cell-to-microorganism, -toxin and -antibody binding; they are used by pathogenic organisms and recognized as ligands by various proteins. Consequently, they present biological and synthetic interests.