EXPLORING THE USE OF N-TETRACHLOROPHTHALOYL- PROTECTED BUILDING BLOCKS FOR THE SYNTHESIS OF CHONDROITIN SULFATE OLIGOSACCHARIDES

摘要

Chondroitin sulfate (CS) is a linear and polyanionic polysaccharide that belongs to the glycosaminoglycan family. CS chains are composed of repetitive disaccharide units of β(1->4)-D-glucuronic acid(GlcA)-β-(1->3)-N-acetyl-D-galactosamine(GalNAc) that may present sulfate groups at various positions. This structural heterogeneity, in terms of sulfation pattern, can be understood as an inherent capacity to encode information and control a wide variety of biological processes. In this context, synthetic CS oligosaccharides are useful tools for the establishment of structure-activity relationships for specific sequences and the design of mimetics that potentially modulate the biological functions of the natural product.