A Novel High Yield Process for Gold Sulfide Nanoparticle Synthesis via Shifting Equilibrium of Self-Assembly Reaction

摘要

This project is focused on a novel process for gold-gold sulfide (QGS) nanoparticle synthesis. GGS nanoparticles have a strong near infrared (nIR) absorbing property, allowing their use in a variety of biomedical applications including cancer therapy. By combining a 1-step self-assembly process and simultaneously performing dialysis, the equilibrium of the reaction is shitted to favor the formation of the nIR-absorbing fraction. This hybrid dialysis based synthesis process, DiaSynth, results in removal of smaller ions and particles during the reaction leading to minimal formation of pure small gold particles within the system. The result is a suspension of nIR absorbing nanoparticles with very little gold colloid contamination, which require minimum further processing for therapeutic or other applications. The purity and properties of these particles match that of GGS nanoparticles produced by the self-assembly process followed by multi-step centrifugation.