Biodegradation and Mechanical Properties of Polylactides for Urological Applications

摘要

In the specialized field of urology there is a need of biopolymers that as implants help in tissue regeneration and then are reabsorbed without any surgery.Polylactides are important medical plastics whose biodegradation and mechanical properties can be controled by copolymerization and/or blending.The aim of this work is to study the structure related mechanical properties and biodegradation behaviour of medical polylactides both in vitro and in vivo in urological medium. poly (L-lactide), poly (D,L-lactide) 53/47, a poly (lactide-co-e-caprolactone) 70/30 and a poly (lactide-co-glycolide) 51/49, all expressed in molar composition, supplied by Purac Biochem (The Netherlands), hereafter termed PLLA, PDLLA, PLCL, PLGA respectively, were analyzed. Since non-biodegradable silicone is often used in urological applications it was taken as a control reference for the in vivo biodegradation study.