An adaptive insulin infusion approach for customized blood glucose regulation of TYPE I diabetic patients

摘要

A combination of dynamic inversion philosophy of nonlinear control with model-following adaptive technique, for robustness of controller, is proposed for control of glucose level as near as possible to basal value in Type I diabetes mellitus patient. Proposed technique exploits Bergman minimal model representing glucose-insulin dynamics. A nominal controller based on the principal of dynamic inversion can treat the patient with nominal values of parameters very effectively, but could fail to treat patients with parameters different than nominal values (worse it may lead to hypoglycaemia). Model-following adaptive controller is augmented to the nominal controller to make nominal controller robust to parameter and model inaccuracies. Simulation results shows the effectiveness of dynamic inversion based glucose level control of realistic patient when augmented with model-following adaptive philosophy.