Direct Laser Writing of Polylactide 3D Scaffolds for Neural Tissue Engineering Applications

摘要

We report on the fabrication of high resolution 3D scaffolds of polylactide-based materials using direct laser writing and we explore their use as neural tissue engineering scaffolds. A critical component for successfully tissue engineer complex 3D tissues from a cell source is the production and utilisation of an appropriate 3D scaffold. Indeed, cells seeded on a flat surface grow typically in a monolayer fashion, while 3D cell cultures can only be achieved via their growth in a 3D micro-environment or scaffold. The success of these scaffolds in their use for tissue engineering is critically dependent on their mechanical properties, surface properties, and microstructure.