Near-infrared optical mammography with broadband spectralimaging for spatially-resolved oximetry

摘要

We report the development of an instrument for diffuse spectral imaging of the human breast operating over the wavelength range 650-900 nm. This instrument images the slightly compressed human breast in a planar geometry by performing a tandem scan, over the x-y plane, of a 3 mm illumination optical fiber and a 5 mm collection optical fiber that are collinear and located on opposite sides of the breast. An edge-correction algorithm accounts for breast thickness variability over the x-y plane, a second-derivative imaging algorithm enhances the display of optical inhomogeneities, and a paired-wavelength spectral method yields oxygenation maps. We report our results of oxygenation mapping in eighteen human subjects, two of which are breast cancer patients, one with a ductal carcinoma in situ, the other with an invasive ductal carcinoma.