Continuous Cell Production from Three Dimensional Hematopoietic Microenvironment in Polyurethane Foam

摘要

In adult humans, the bone marrow is the site for hematopoiesis. In this site, hematopoietic stem cells (HSCs) maintain, self-renew and differentiate into all blood cells. HSCs adhere to the surface of trabecular bone through bone marrow stromal cells.The cell-cell or cell-extra cellar matrix (ECM) interactions maintain the physiological hematopoietic environment.