Pompilidotoxins, Peptide Neurotoxins in Solitary Wasp Venom Blocking Sodium Channel Inactivation

摘要

Pompilidotoxins (PMTXs), the small peptides consisting of 13 amino acids isolated from solitary wasp venoms, have been known to slow Na channel inactivation. By using a series of six PMTX analogs, we conducted a thorough study of the effects of PMTXs on Na current inactivation in seven mammalian voltage-gated sodium channel isoforms (NGSCs) and one insect VGSC (DmNa_v1), and found that three distinct types of PMTX-effects could be distinguished.