A Rapid and Comprehensive Technique for Viral and Contaminant Protein Identification in Influenza Vaccines

摘要

The major challenge for the analysis of these products by MS is the very high degree of homology across thousands of sequenced influenza strains. However, with this methodology, the combination of innovative sample preparation, excellent HPLC fidelity, accurate MS and non-redundant replicate MS/MS analyses using exclusion lists generates extensive protein sequence coverage, which frequently allows confident assignment of strain identity.