The implementation of the time-stamping, multi-hit PlmMS sensor in combination with a commercially available time-of-flight mass spectrometer

摘要

The work presented here is a first step to creating a fully functional imaging mass spectrometer by simple modifications to a conventional ToF-MS instrument. By adding a fast camera, such as the PlmMS camera, it should be possible to analyse tissue samples, or arrays of samples with a very high throughput. In this mode a small cluster of pixels on the PlmMS camera would act as a single MS independently of the next cluster of pixels. Images of tissue samples have been obtained before with the PlmMS camera and a modified molecular dynamics instrument. With this new apparatus it should be possible to identify pharmacologically important species and so to greally increase the practical output of many analytical experiments [6].