Exploring Low And High pH Eluents Using A New Silica-Based Extended pH Range C18 Column For Analysis Of Amphetamines Opiates From Urine By LC-MS

摘要

Eluent pH is a powerful approach for exploringchromatographic selectivityin method development & isolations. The ACE SuperC18 has enhanced retentivity that can be helpful for LC-MS work as higher organic content is needed for elution which is ideal for analyte ionisation. Amphetamine, morphine and their related species and metabolites can be measured at low levels usingLC-MS/MS with the ACE SuperC18 at low and high eluent pH. The high pH work is shown. The ACE. SuperC18 provides chromatographersand method developerswith an NEWselectivity option with an extended pH range and LC-MSanalyses.