Targeted Analyte Detection For Improving the Detection Limit of Mass Spectrometry

摘要

(1) Evaluation of targeted analyte detection (TAD) using three peptides in simple and complex background experiment shows that TAD significantly improves the sensitivity and detection limit of the analytes of interest; (2) The optimum exogenous concentration for highest LOD improvement was shown to be the original LOD of the analyte of interest; (3) TAD is a generic method that can be applied to a wide range of analytes and instruments without the necessity of costly hardware modifications.