Optimization of a Robust LC/MS/MS Assay for the Quantitation of an Unstable Compound to Support Clinical Studies

机译：优化鲁棒LC / MS / MS测定以定量不稳定化合物以支持临床研究

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The critical steps for the previously validated assay for bortezomib have been optimized for more routine analysis. Freeze/thaw stability has been demonstrated across all QC sample concentrations to 4 cycles. The optimization of the experimental approach has removed a persistent negative bias observed for QC samples. Incurred sample reanalysis has shown that the results from the assay are reproducible.

机译：用于Bortezomib的先前验证的测定的关键步骤已经针对更多常规分析进行了优化。在所有QC样品浓度上证明了冷冻/解冻稳定性至4个循环。实验方法的优化已经去除了对QC样品观察到的持续阴性偏差。发生样品再分析表明，测定结果是可重复的。

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《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2011年||共1页
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Christopher W. Binns; Kathy Jo Champion; Wenyi Hua; Emily King; Chris Nattrass; Kimberly L. Norwood; Daniel E. Mulvana; John R. Perkins;
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Optimization of a Robust LC/MS/MS Assay for the Quantitation of an Unstable Compound to Support Clinical Studies

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