Differential proteomic analysis of the hippocampus in Homer2 knockout and wildtype mice: molecular implications for alcohol aversion.

摘要

Shotgun proteomic analysis indicates that Homer2 deletion alters global protein expression. Differential display analyses identified the differential expression of Homer2 associated proteins. These data suggest that differentially expressed proteins provide a readout as to the downstream functional effectors of Homer2 protein. Use a subset of these differentially expressed proteins in multiplexed selection reaction monitoring (SRM) analysis in other brain regions during the time course of well-described paradigms for excessive alcohol drinking and withdrawal.