Investigation of Model BOC-Hydroxylamine/Metal Complexes via IRMPD Spectroscopy and DFT Modeling

摘要

The IRMPD/DFT combination method has been used steadily in the recent years to study the interactions between metal ions and biomolecules [1-5]. The hydroxamate moiety, as seen below, has long been studied for its metal binding properties [6,7]. This functionality gives siderophores their iron binding properties, making Fe~(2+) more bioavailable and facilitating movement through cellular membranes [8]. In addition to iron, the hydroxamate binding propensity for heavy metals has led to increased research in the area of metal chelation therapy [9,10]. Past work from our group studied the binding of actinides, specifically the uranyl ion, to a trihydroxamate siderophore as a way to identify contamination levels at sites housing radioactive waste [11]. In the final chapter of this thesis, the focus will shift from metal-chlorate interactions to something with more biological relevance.