The Fat Depot-Specific Secretome of Human Fat Cell Progenitors

摘要

The secretomes of subcutaneous and omental fat depots are distinct, as shown by protein expression patterns using the label-free quantitative method, consistent with our genome-wide expression analysis. Around 200 secreted proteins that vary significantly between different fat depots more than two-fold were identified. Many of the overexpressed proteins in omental preadipocytes are involved in immune response pathways. Overall, the omental secretome was more pro-inflammatory, atherogenic, and likely to induce insulin resistance than the subcutaneous secretome. Furthermore, differences were evident despite prolonged culture of progenitors from the 2 depots of the same subjects under identical conditions, suggesting preadipocytes from different fat depots are inherently distinct.