c-HA-RAS (VAL-12) MUTATIONS IN IMMORTAL BREAST EPITHELIAL CELLS

摘要

Normal Ras mediates the effects of external growth signals, while p53 is associated with the regulation of the duration of Ras-mediated growth factor signalling, cell cycle progression, programmed cell death and cell protection against malignant transformation. Mutations to- or deletion of- the 9p21 locus affects the tumour suppressor activity of p53, and, in association with a Val-12 c-Ha-ras mutation, have been associated with invasion and malignant progression in human epithelial cancers.