Membrane Associated Structure of a Ghrelin Agonist as Determined by NMR

摘要

We have undertaken the structural characterization of a ghrelin inverse agonist, sequentially related to substance P, using high-resolution NMR methods. Given the evidence of a membrane associated pathway to interaction with the receptor, we carried out structural studies in the presence of a membrane mimetic. Based on the structural results we hope to understand the structural requirements for agonists versus antagonism.