Studies on a Mutual Prodrug of Sulfamethoxazole and Nalidixic acid

摘要

The potential of microorganisms is tremendous with respect to their detrimental and perhaps outweighs the beneficial effects with respect to health of a human being. The search for new antibacterial agents is one of the most challenging tasks of the current medicinal chemistry. Nalidixic acid is highly effective against infections with Gram- bacteria, but it is ineffective against most Gram+ bacteria whereas sulfamethoxazole is a broad spectrum antibacterial agent having good action against infections caused by Gram+ bacteria as well. In view of these facts it was considered worthwhile to synthesize a mutual prodrug of sulfamethoxazole and nalidixic acid. The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the Gram+ and Gram- bacteria.