PREPARATION OF HYDROXYAPATITE /CALCIUM ALGINATE COMPOSITE GEL AND APPLICATION TO MEDICAL MATERIAL

摘要

In this research work, we prepared hydroxyapatite from CaCl{sub}2 (100mM-1000mM) and (NH{sub}4) {sub}2HPO{sub}4 (60mM-600mM) in calcium alginate gel under the room temperature and atmospheric pressure. Surface structure of composite materials was investigated with optical microscope and scanning electron microscope. Composite gels were evaluated characteristic of electrical stimulus. The amount of hydroxyapatite crystal in polymer gel was increased with concentration of (NH{sub}4) {sub}2HPO{sub}4 and CaCl{sub}2. Calcium alginate gel containing hydroxyapatite had lower crosslinking density and porous surface structure. Hydroxyapataite / calcium alginate composite gels were contracted with applied voltage. It was estimated that composite gels containing drug were released.